Serena Williams Says GLP-1 Medication Helped Her Lose 31 Pounds

Tennis legend Serena Williams has revealed that she turned to a GLP-1 weight loss medication to help manage her health after giving birth to her second daughter.

In a recent interview with TODAY, the 23-time Grand Slam champion said she began taking the drug about a year ago and has since lost 31 pounds. While she did not specify which GLP-1 medication she is on, Williams explained that it was a decision she reached after struggling with weight fluctuations despite years of training and strict diets.

“I was on and off (the medication) and now completely on,” she said. “It was a really good decision I had to make for my life. I tried everything — running, walking for hours, even being vegan and vegetarian — but I just couldn’t get back to where I needed to be for my health.”

Williams, 42, noted that her weight challenges intensified after her pregnancies. She shared that persistent knee issues and difficulty returning to her pre-pregnancy fitness level affected her both personally and professionally.

Since starting the medication, she says her blood sugar levels have improved, her joints feel “lighter,” and she has not experienced any side effects. “I put my body through a lot. I understand there are side effects, but I didn’t have any,” she said.

The former world No. 1 also addressed the stigma surrounding weight loss drugs, admitting she initially struggled with the idea. “A misconception is that it’s a shortcut. But as an athlete who has tried everything, I can say this was about reaching a healthy place — not taking shortcuts.”

Asked whether she intends to continue the treatment long-term, Williams said yes. “After having my kids, my body felt like it was missing something. I don’t know if it’s something the GLP-1 has, but I finally feel normal again.”

GLP-1 drugs, also called GLP-1 receptor agonists, mimic a hormone the body releases after eating, reducing appetite, slowing digestion, and promoting fullness. They are also approved for diabetes management, as they stimulate insulin release.